The Portuguese striker, 32, has been rested for four of Real's last five away league games to ensure he is in prime condition for their assault on becoming the first side to retain the Champions League.
Real, though, haven't missed the four-time World Player of the Year, winning all eight La Liga games in his absence this season.
Ronaldo scored all three of Real's goals as they claimed a 3-0 semi-final, first leg lead over Atletico with the second leg to come at the Vicente Calderon on Wednesday.
Goalkeeper Keylor Navas and defender Raphael Varane are also rested, whilst Dani Carvajal misses out through injury.
Real are tied with Barcelona at the top of La Liga, but have a game in hand over their title rivals.
